Biography
 Preface
 CHAPTER 1 Introduction
  1.1 What is Longitudinal Data Analysis?
  1.2 History of Longitudinal Analysis and its Progress
  1.3 Longitudinal Data Structures
   1.3.1 Multivariate Data Structure
   1.3.2 Univariate Data Structure
   1.3.3 Balanced and Unbalanced Longitudinal Data
  1.4 Missing Data Patterns and Mechanisms.
  1.5 Sources of Correlation in Longitudinal Processes
  1.6 Time Scale and the Number of Time Points
  1.7 Basic Expressions of Longitudinal Modeling
  1.8 Organization of the Book and Data Used for Illustrations.
   1.8.1 Randomized Controlled Clinical Trial on the Effectiveness of Acupuncture Treatment on PTSD
   1.8.2 Asset and Health Dynamics Among the Oldest Old (AHEAD)
 CHAPTER 2 Traditional Methods of Longitudinal Data Analysis
  2.1 Descriptive Approaches
   2.1.1 Time Plots of Trends
   2.1.2 Paired t-Test
   2.1.3 Effect Size Between Two Means and its Confi dence Interval
   2.1.4 Empirical Illustration: Descriptive Analysis on the Effectiveness of Acupuncture Treatment in Reduction of PTSD Symptom Severity
  2.2 Repeated Measures ANOVA
   2.2.1 Specifi cations of One-Factor ANOVA
   2.2.2 One-Factor Repeated Measures ANOVA
   2.2.3 Specifi cations of Two-Factor Repeated Measures ANOVA
   2.2.4 Empirical Illustration: A Two-Factor Repeated Measures ANOVA – The Effectiveness of Acupuncture Treatment on PCL Revisited
  2.3 Repeated Measures MANOVA
   2.3.1 General MANOVA
   2.3.2 Hypothesis Testing on Effects in MANOVA
   2.3.3 Repeated Measures MANOVA
   2.3.4 Empirical Illustration: A Two-Factor Repeated Measures MANOVA on the Effectiveness of Acupuncture Treatment on Two Psychiatric Disorders
  2.4 Summary
 CHAPTER 3 Linear Mixed-Effects Models
  3.1 Introduction of Linear Mixed Models: Three Cases
   3.1.1 Case I: One-Factor Linear Mixed Model with Random Intercept
   3.1.2 Case II: linear Mixed Model with Random Intercept and Random Slope.
   3.1.3 Case III: Linear Mixed Model with Random Effects and Three Covariates
  3.2 Formalization of Linear Mixed Models
   3.2.1 General Specifi cation of Linear Mixed Models
   3.2.2 Variance–Covariance Matrix and Intraindividual Correlation
   3.2.3 Formalization of Variance–Covariance Components
  3.3 Inference and Estimation of Fixed Effects In Linear Mixed Models
   3.3.1 Maximum Likelihood Methods
   3.3.2 Statistical Inference and Hypothesis Testing on Fixed Effects
   3.3.3 Missing Data
  3.4 Trend Analysis
   3.4.1 Polynomial Time Functions
   3.4.2 Methods to Reduce Collinearity in Polynomial Time Terms
   3.4.3 Numeric Checks on Polynomial Time Functions
  3.5 Empirical Illustrations: Application of Two Linear Mixed Models
   3.5.1 Linear Mixed Model on Effectiveness of Acupuncture Treatment on PCL Score
   3.5.2 Linear Mixed Model on Marital Status and Disability Severity in Older Americans
  3.6 Summary
 CHAPTER 4 Restricted Maximum Likelihood and Inference of Random Effects in Linear Mixed Models
  4.1 Overview of Bayesian Inference
  4.2 Restricted Maximum Likelihood Estimator
   4.2.1 MLE Bias in Variance Estimate in General Linear Models
   4.2.2 Specifi cation of REML in General Linear Models
   4.2.3 REML Estimator in Linear Mixed Models
   4.2.4 Justifi cation of the Restricted Maximum Likelihood Method
   4.2.5 Comparison Between ML and REML Estimators
  4.3 Computational Procedures
   4.3.1 Newton–Raphson Algorithm
   4.3.2 Expectation–Maximization Algorithm
  4.4 Approximation of Random Effects in Linear Mixed Models
   4.4.1 Best Linear Unbiased Prediction
   4.4.2 Shrinkage and Reliability
  4.5 Hypothesis Testing on Variance Component G
  4.6 Empirical Illustrations: Linear Mixed Models with REML
   4.6.1 Linear Mixed Model on Effectiveness of Acupuncture Treatment on PCL Score
   4.6.2 Linear Mixed Model on Marital Status and Disability Among Older Americans
  4.7 Summary
 CHAPTER 5 Patterns of Residual Covariance Structure
  5.1 Residual Covariance Pattern Models with Equal Spacing
   5.1.1 Compound Symmetry (CS)
   5.1.2 Unstructured Pattern (UN)
   5.1.3 Autoregressive Structures – AR(1) and ARH(1)
   5.1.4 Toeplitz Structures – TOEP and TOEPH
  5.2 Residual Covariance Pattern Models with Unequal Time Intervals
   5.2.1 Spatial Power Model – SP(POW)
   5.2.2 Spatial Exponential Model – SP(EXP)
   5.2.3 Spatial Gaussian Model – SP(GAU)
   5.2.4 Hybrid Residual Covariance Model
  5.3 Comparison of Covariance Structures
  5.4 Scaling of Time as a Classifi cation Factor
   5.4.1 Scaling Approaches for Classifi cation Factors.
   5.4.2 Coding Schemes of Time as a Classifi cation Factor.
  5.5 Least Squares Means, Local Contrasts, and Local Tests
   5.5.1 Least Squares Means
   5.5.2 Local Contrasts and Local Tests
  5.6 Empirical Illustrations: Estimation of Two Linear Regression Models
   5.6.1 Linear Regression Model on Effectiveness of Acupuncture Treatment on PCL Score
   5.6.2 Linear Regression Model on Marital Status and Disability Severity Among Older Americans
  5.7 Summary
 CHAPTER 6 Residual and Infl uence Diagnostics
  6.1 Residual Diagnostics
   6.1.1 Types of Residuals in Linear Regression Models
   6.1.2 Semivariogram in Random Intercept Linear Models
   6.1.3 Semivariogram in the Linear Random Coeffi cient Model
  6.2 Infl uence Diagnostics
   6.2.1 Cook’s D and Related Infl uence Diagnostics
   6.2.2 Leverage
   6.2.3 DFFITS, MDFFITS, COVTRACE, and COVRATIO Statistics
   6.2.4 Likelihood Displacement Statistic Approximation
   6.2.5 LMAX Statistic for Identifi cation of Infl uential Observations
  6.3 Empirical Illustrations on Infl uence Diagnostics
   6.3.1 Infl uence Checks on Linear Mixed Model Concerning Effectiveness of Acupuncture Treatment on PCLScore
   6.3.2 Infl uence Diagnostics on Linear Mixed Model Concerning Marital Status and Disability Severity Among Older Americans
  6.4 Summary
 CHAPTER 7 Special Topics on Linear Mixed Models
  7.1 Adjustment of Baseline Response in Longitudinal Data Analysis
   7.1.1 Adjustment of Baseline Score and the Lord’s Paradox
   7.1.2 Adjustment of Baseline Score in Longitudinal Data Analysis
   7.1.3 Empirical Illustrations on Adjustment of Baseline Score
  7.2 Misspecifi cation of the Assumed Distribution of Random Effects
   7.2.1 Heterogeneity Linear Mixed Model
   7.2.2 Nonnormal Random Effect Distribution in Linear Mixed Models
   7.2.3 Best Predicted Random Effects in Different Distributions
   7.2.4 Empirical Illustration: Comparison Between Blup and Least Squares Means.
  7.3 Pattern-Mixture Modeling
   7.3.1 Classifi cation of Heterogeneous Groups
   7.3.2 Basic Theory of Pattern-Mixture Modeling
   7.3.3 Pattern-Mixture Model.
   7.3.4 Empirical Illustration of Pattern-Mixture Modeling
  7.4 Summary
 CHAPTER 8 Generalized Linear Mixed Models on Nonlinear Longitudinal Data
  8.1 A Brief Overview of Generalized Linear Models
  8.2 Generalized Linear Mixed Models and Statistical Inferences
   8.2.1 Basic Specifi cations of Generalized Linear Mixed Models
   8.2.2 Statistical Inference and Likelihood Functions
   8.2.3 Procedures of Maximization and Hypothesis Testing on Fixed Effects
   8.2.4 Hypothesis Testing on Variance Components
  8.3 Methods of Estimating Parameters in Generalized Linear Mixed Models
   8.3.1 Penalized Quasi-Likelihood Method
   8.3.2 Marginal Quasi-Likelihood Method
   8.3.3 The Laplace Method
   8.3.4 Gaussian Quadrature and Adaptive Gaussian Quadrature Methods
   8.3.5 Markov Chain Monte Carlo Methods
  8.4 Nonlinear Predictions and Retransformation of Random Components
   8.4.1 Best Linear Unbiased Prediction Based on Linearization
   8.4.2 Empirical Bayes BLUP
   8.4.3 Retransformation Method
  8.5 Some Popular Specifi c Generalized Linear Mixed Models
   8.5.1 Mixed-Effects Logistic Regression Model
   8.5.2 Mixed-Effects Ordered Logistic Model
   8.5.3 Mixed-Effects Multinomial Logit Regression Models
   8.5.4 Mixed-Effects Poisson Regression Models
   8.5.5 Survival Models
  8.6 Summary
 CHAPTER 9 Generalized Estimating Equations (GEEs) Models
  9.1 Basic Specifi cations and Inferences of GEEs
   9.1.1 Specifi cations of “Naïve” Model with Independence Hypothesis
   9.1.2 Basic Specifi cations of GEEs
   9.1.3 Specifi cations of Working Correlation Matrix
   9.1.4 Quasi-Likelihood Information Criteria for GEEs
  9.2 Other GEE Approaches
   9.2.1 Prentice’s GEE Approach
   9.2.2 Zhao and Prentice’s GEE Method (GEE2).
   9.2.3 GEE Models on Odds Ratios
  9.3 Relationship Between Marginal and Random-Effects Models
   9.3.1 Comparison Between the Two Approaches
   9.3.2 Use of GEEs to Fit a Conditional Model
  9.4 Empirical Illustration: Effect of Marital Status on Disability Severity in Older Americans
  9.5 Summary
 CHAPTER 10 Mixed-Effects Regression Model for Binary Longitudinal Data
  10.1 Overview of Conventional Logistic and Probit Regression Models
  10.2 Specifi cation of Random Intercept Logistic Regression Model
  10.3 Specifi cation of Random Coeffi cient Logistic Regression Model
  10.4 Inference of Mixed-Effects Logit Model
  10.5 Approximation of Variance for Predicted Response Probability
  10.6 Interpretability of Regression Coeffi cients and Odds Ratios
  10.7 Computation of Conditional Effect and Conditional Odds Ratio for a Covariate
  10.8 Empirical Illustration: Effect of Marital Status on Probability of Disability Among Older Americans
   10.8.1 Analytic Plan
   10.8.2 Analytic Steps with SAS Programs
   10.8.3 Analytic Results
   10.8.4 Nonlinear Predictions
   10.8.5 Graphical Results
  10.9 Summary.
 CHAPTER 11 Mixed-Effects Multinomial Logit Model for Nominal Outcomes
  11.1 Overview of Multinomial Logistic Regression Model
  11.2 Mixed-Effects Multinomial Logit Models and Nonlinear Predictions
  11.3 Estimation of Fixed and Random Effects
  11.4 Approximation of Variance–Covariance Matrix on Probabilities
  11.5 Conditional Effects of Covariates on Probability Scale.
  11.6 Empirical Illustration: Marital Status and Longitudinal Trajectories of Disability and Mortality AmongOlder Americans.
   11.6.1 Data, Measures, and Models
   11.6.2 Analytic Steps with SAS Programs
   11.6.3 Analytic Results and Nonlinear Predictions
   11.6.4 Conditional Effects of Marital Status
   11.6.5 Graphical Analysis on Nonlinear Predictions
  11.7 Summary
 CHAPTER 12 Longitudinal Transition Models for Categorical Response Data
  12.1 Overview of Two-Time Multinomial Transition Modeling
  12.2 Longitudinal Transition Models with Only Fixed Effects
  12.3 Mixed-Effects Multinomial Logit Transition Models
   12.3.1 Random Intercept Multinomial Logit Transition Model
   12.3.2 Random Coeffi cient Multinomial Logit Transition Model
   12.3.3 Statistical Inference of Mixed-Effects Multinomial Logit Transition Model
   12.3.4 Approximation of Variance–Covariance Matrix for Transition Probabilities
   12.3.5 Creation of Separate Multinomial Logit Transition Models
  12.4 Empirical Illustration: Predicted Transition Probabilities in Functional Status and Marital Status Among Older Americans
   12.4.1 Measures, Models, and SAS Programs
   12.4.2 Prediction of Transition Probabilities
   12.4.3 Effects of Marital Status on Transition Probabilities
  12.5 Summary
 CHAPTER 13 Latent Growth, Latent Growth Mixture,and Group-Based Models
  13.1 Overview of Structural Equation Modeling
  13.2 Latent Growth Model
  13.3 Latent Growth Mixture Model
  13.4 Group-Based Model
  13.5 Empirical Illustration: Effect of Marital Status on ADL Count Among Older Americans Revisited
  13.6 Summary
 CHAPTER 14 Methods for Handling Missing Data
  14.1 Mathematical Defi nitions of MCAR, MAR, and MNAR
  14.2 Methods Handling Missing at Random
   14.2.1 Simple Approaches
   14.2.2 Last Observation Carried Forward
   14.2.3 Multiple Imputations.
   14.2.4 Comparison Between MI and Shrinkage
   14.2.5 Empirical Illustration: Comparison of AnalyticResults with and without Multiple Imputationson Missing Data
  14.3 Methods Handling Missing Not at Random.
   14.3.1 Impact of Nonignorable Missing Data in Longitudinal Data Analysis
   14.3.2 Selection Model on MNAR
   14.3.3 Pattern Mixture Model on MNAR.
   14.3.4 Nonparametric Regression Model on NonignorableMissing Data
   14.3.5 Empirical Illustration: Comparison of Different Methods for Handling Nonignorable Missing Data
  14.4 Summary
 Appendix A Orthogonal Polynomials
 Appendix B The Delta Method
 Appendix C Quasi-Likelihood Functions and Properties
 Appendix D Model Specifi cation and SAS Program for Random Coeffi cient Multinomial Logit Model on Health State Among Older Americans
 References
 Subject Index
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